The Mets drew first blood in round two of the Subway Series Friday night.
The Amazins scored five runs in the first inning, capped by a three-run home run by Ike Davis.
Alex Rodriguez, Andruw Jones and Robinson Cano homered for the Bombers to cut the deficit but in the end, the Mets held on to win 6-4.
Before the game, Johan Santana received a key to the city from Mayor Bloomberg in honor of his no-hit game earlier this year.
It was the fourth time a member or members of the New York Mets have received a key to the city.